Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a Disposable Food Containers rare autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability accompanied by DNA hypomethylation.Pathological variants in the DNMT3B, ZBTB24, CDCA7, or HELLS genes underlie its etiology.Activated lymphocytes

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Harp Seals: Monitors of Change in Differing Ecosystems

Harp seals are the most abundant marine mammal in the north Atlantic.As an ice obligatory predator, they reflect changes in their environment, particularly during a period of climatic change.As the focus of a commercial hunt, a large historic data set exists that can be used to quantify changes.There are three populations of harp seals: White Sea/B

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Remoteness and its impact on the potential for mental health initiatives in criminal courts in Nunavut, Canada

Remoteness in the isolated communities of Nunavut, Canada adversely affects access to mental health services.Mental health initiatives in criminal courts exist in many cities to offer healthcare alternatives to regular criminal court processing for people affected by mental illness.These initiatives do not exist in Nunavut.A qualitative multiple-ca

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